{"id":3492,"date":"2021-11-02T10:44:13","date_gmt":"2021-11-02T09:44:13","guid":{"rendered":"https:\/\/www.lvbe.uha.fr\/?page_id=3492"},"modified":"2026-09-28T14:11:29","modified_gmt":"2026-09-28T12:11:29","slug":"alexia-grau","status":"publish","type":"page","link":"https:\/\/www.lvbe.uha.fr\/index.php\/equipe\/chercheurs-venus-collaborer-au-lvbe\/alexia-grau\/","title":{"rendered":"Dr. Alexia GRAU"},"content":{"rendered":"<p>Docteur \u00e8s sciences au LVBE et attach\u00e9e temporaire d&rsquo;enseignement et de recherche (ATER)<\/p>\n<div class=\"su-row\">\n<div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\n<h1>Activit\u00e9s de recherche<\/h1>\n<h2>Th\u00e8se soutenue le 13 d\u00e9cembre 2024<\/h2>\n<ul>\n<li>Depuis Novembre 2021<\/li>\n<\/ul>\n<p>sous la direction du Pr J. CHONG<br \/>\nUniversit\u00e9 de Haute-Alsace \/ Laboratoire Vigne, Biotechnologies et Environnement<em> EA 3991, <\/em><em>Colmar (68) <\/em><\/p>\n<p><strong><em>Maladies du bois de la vigne\u00a0: Compr\u00e9hension des m\u00e9canismes de tol\u00e9rance chez la plante et \u00e9tude d\u2019effecteurs de <\/em><\/strong><strong>Botryosphaeriaceae<\/strong><\/p>\n<p>Cette th\u00e8se se concentre sur 2 aspects essentiels qui r\u00e9gissent l\u2019interaction entre la plante et ses pathog\u00e8nes\u00a0:<\/p>\n<p>1) la <strong>tol\u00e9rance de la plante<\/strong>\u00a0<em>via<\/em> l\u2019\u00e9tude de l\u2019impact du statut carbon\u00e9 sur la tol\u00e9rance de la plante face au pathog\u00e8ne<\/p>\n<p>2) les <strong>facteurs de virulence du microorganisme<\/strong>. Pour cela je me concentre sur la compr\u00e9hension des r\u00f4les de 6 effecteurs prot\u00e9iques identifi\u00e9s chez <em>Neofusicoccum parvum <\/em>et ayant une affinit\u00e9 avec l\u2019arsenic<\/p>\n<h1>Dipl\u00f4mes et formations<\/h1>\n<p><strong>Master Gestion de la Qualit\u00e9 des Productions V\u00e9g\u00e9tales<\/strong><\/p>\n<p>Avignon Universit\u00e9 \u00b7 2019 \u2013 2021 \u00b7 Mention\u00a0: Bien<\/p>\n<p><em>Avignon (84)<\/em><\/p>\n<p><strong>Licence Science de la Vie et de la Terre \u2013 Agrosciences<\/strong><\/p>\n<p>Avignon Universit\u00e9 \u00b7 2016 \u2013 2019 \u00b7 Mention\u00a0: Bien<\/p>\n<p><em>Avignon (84)<\/em><\/p>\n<p><strong>Premi\u00e8re Ann\u00e9e Commune aux \u00c9tudes de Sant\u00e9<\/strong><\/p>\n<p>Aix Marseille universit\u00e9 de m\u00e9decine \u00b7 2014 \u2013 2016<\/p>\n<p><em>Marseille (13)<\/em><\/p>\n<p><strong>Baccalaur\u00e9at S<\/strong><\/p>\n<p>Lyc\u00e9e Isma\u00ebl Dauphin \u00b7 2011 \u2013 2014 \u00b7 Mention\u00a0: Assez Bien<\/p>\n<p><em>Cavaillon (84)<\/em><\/p>\n<\/div><\/div>\n<div class=\"su-column su-column-size-1-2\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\n<h1>Exp\u00e9riences professionnelles<\/h1>\n<ul>\n<li><strong>Stage de Master 2 <\/strong>\u00b7 F\u00e9vrier \u2013 Aout 2021<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\"><strong>INRAe &#8211; PACA<\/strong> \u00b7 \u00c9quipe D.A.D.I.<\/p>\n<p style=\"padding-left: 40px;\"><strong><em>Validation fonctionnelle de QTL responsables de la teneur en sucres et acides chez la tomate par Genome Editing<\/em><\/strong><\/p>\n<ul>\n<li><strong>Stage de Master 1 <\/strong>\u00b7 Mai \u2013 Aout 2020<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\"><strong>Avignon Universit\u00e9<\/strong><\/p>\n<p style=\"padding-left: 40px;\"><strong><em>\u00c9tude des r\u00e9ponses mol\u00e9culaires du p\u00eacher (<\/em><\/strong><strong><em>Prunus persica) \u00e0 l\u2019infestation par le puceron vert (Myzus persicae)\u00a0: r\u00f4les du stress oxydatif<\/em><\/strong><\/p>\n<ul>\n<li><strong>Stage de Licence 3 &#8211; <\/strong><em>Technicien de laboratoire<\/em> \u00b7 Avril \u2013 Juillet 2019<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\"><strong>INRA \u2013 PACA <\/strong>\u00b7 \u00c9quipe D.A.D.I.<\/p>\n<p style=\"padding-left: 40px;\"><strong><em>Caract\u00e9risation de m\u00e9tabolites secondaires de la p\u00eache (<\/em><\/strong><strong>Prunus persica<em>) affectant la pathog\u00e9nicit\u00e9 de <\/em>Monilinia spp.<\/strong><\/p>\n<h1>Comp\u00e9tences<\/h1>\n<p><strong>Biologie cellulaire<\/strong>\u00a0<strong>et mol\u00e9culaire <\/strong>:<\/p>\n<ul>\n<li>Microscopie optique (tissus v\u00e9g\u00e9taux et microorganismes)<\/li>\n<li>Extraction ADN et ARN<\/li>\n<li>PCR, qPCR<\/li>\n<li>HRM<\/li>\n<\/ul>\n<p><strong>Microbiologie\/Biotechnologies<\/strong> :<\/p>\n<ul>\n<li>Culture <em>in vitro<\/em> de plantes, bact\u00e9ries et champignons.<\/li>\n<li>Clonage<\/li>\n<li>Cr\u00e9ation CRISPR\/Cas9<\/li>\n<\/ul>\n<p><strong>Biochimie <\/strong>:<\/p>\n<ul>\n<li>\u00c9lectrophor\u00e8se,<\/li>\n<li>HPLC (compos\u00e9s ph\u00e9noliques)<\/li>\n<li>Dosage d\u2019activit\u00e9 enzymatique<\/li>\n<\/ul>\n<p><strong>Bio-informatique<\/strong><\/p>\n<ul>\n<li>Analyse de s\u00e9quences : Codon Code, Serial Cloner<\/li>\n<li>Design d\u2019amorces<\/li>\n<li>Bio-Rad CFX Maestro<\/li>\n<li>Uniprot, EMBOSS<\/li>\n<\/ul>\n<h3>Langues et Informatique<\/h3>\n<p><strong>Anglais <\/strong>\u00a0Niveau Avanc\u00e9<\/p>\n<p><strong>\u00a0 Espagnol <\/strong>Niveau D\u00e9butant<\/p>\n<p><strong>Informatique <\/strong>Pack Office R, R Studio<\/p>\n<\/div><\/div>\n<\/div>\n<div class=\"su-tabs su-tabs-style-default su-tabs-mobile-stack\" data-active=\"1\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-tabs-nav\"><span class=\"\" data-url=\"\" data-target=\"blank\" tabindex=\"0\" role=\"button\">Publications scientifiques avec comit\u00e9 de lecture<\/span><span class=\"\" data-url=\"\" data-target=\"blank\" tabindex=\"0\" role=\"button\">Communications par affiches<\/span><span class=\"\" data-url=\"\" data-target=\"blank\" tabindex=\"0\" role=\"button\">Communications Orales<\/span><\/div><div class=\"su-tabs-panes\"><div class=\"su-tabs-pane su-u-clearfix su-u-trim\" data-title=\"Publications scientifiques avec comit\u00e9 de lecture\">\n<h2>Publications scientifiques avec comit\u00e9 de lecture<\/h2>\n<ul>\n<li><strong><span lang=\"EN-US\">Whole plant metabolomic analysis reveals contrasted responses in tolerant and susceptible grapevine cultivars to infection with different isolates of <em>Neofusicoccum parvum<\/em>, a major trunk disease fungus<\/span>. Alexia Laura GRAU,<\/strong> Nathalie LACRAMPE, Mary-Lor\u00e8ne GODDARD et\u00a0Julie CHONG<strong>.\u00a0 <\/strong>9 septembre 2026 BMC Plant Biology <a href=\"https:\/\/doi.org\/10.1186\/s12870-026-09951-3\">https:\/\/doi.org\/10.1186\/s12870-026-09951-3<\/a>[\/su_service]<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Characterization of<\/strong><strong><em> Neofusicoccum parvum<\/em><\/strong><strong> small secreted proteins belonging to Alt a1 and cerato-platanin families affecting defenses in <\/strong><strong><em>Nicotiana benthamiana<\/em><\/strong><strong> and<\/strong><strong><em> Vitis vinifera. <\/em><\/strong><strong>Alexia Laura Grau, <\/strong>Romain J. G. Pierron, Charlotte Doerr, H\u00e9l\u00e8ne Laloue, Mary-Lor\u00e8ne Goddard, Julie Chong.<strong> 2025<\/strong> <em>Physiological and Molecular Plant Pathology <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0885576525000980?utm_campaign=STMJ_219742_AUTH_SERV_PA&amp;utm_medium=email&amp;utm_acid=151039663&amp;SIS_ID=&amp;dgcid=STMJ_219742_AUTH_SERV_PA&amp;CMX_ID=&amp;utm_in=DM552106&amp;utm_source=AC_\"><strong>Volume 138, July 2025, 102659<\/strong><\/a><\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Review: Pathogenicity Factors of Botryosphaeriaceae Associated with Grapevine Trunk Diseases: New Developments on Their Action on Grapevine Defense Responses. <\/strong>Marie Belair, <strong>Alexia Laura Grau<\/strong>, Julie Chong, Xubin Tian\u00a0 Jiaxin Luo , Xin Guan\u00a0 and Flora Pensec<em>.\u00a0<\/em>Pathogens <strong>2022<\/strong>, 11, 951. <a href=\"https:\/\/doi.org\/10.3390\/pathogens11080951\"><strong>DOI:\u00a0<\/strong><\/a>10.3390\/pathogens11080951<\/li>\n<\/ul>\n<\/div>\n<div class=\"su-tabs-pane su-u-clearfix su-u-trim\" data-title=\"Communications par affiches\">\n<h2>Communications par Affiches<\/h2>\n<ul>\n<li><strong>17\u00e8mes Journ\u00e9es Scientifiques du R\u00e9seau Francophone de M\u00e9tabolomique et Fluxomique<\/strong>,\u201c<em>New R Shiny applications designed to improve the metabolomics workflow have highlighted the impact of Neofusicoccum parvum on grapevine metabolism<\/em>\u201d Diagne, A.; Lacrampe, N.; Beaurin, A.; Delgrande, T.; Balta, I.; Laloue, H.; <strong>Grau, A.<\/strong>; Pierron, R.; Chong, J.;\u00a0\u00a0<u>Goddard, M.-L.<\/u> \u00a0June 11-13, <strong>2025,<\/strong> Paris, France.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>12<\/strong><strong><sup>\u00e8me<\/sup><\/strong><strong> Congr\u00e8s Mondial des Pathologies V\u00e9g\u00e9tales,<\/strong> Lyon en France du 20 au 25 ao\u00fbt <strong>2023<\/strong>. Role of six effectors with arsenic affinity on the pathogenicity of <em>Neofusicoccum parvum<\/em>.<strong> A. Grau<\/strong>, R. Pierron, M. L. Goddard et J. Chong.<\/li>\n<\/ul>\n<\/div>\n<div class=\"su-tabs-pane su-u-clearfix su-u-trim\" data-title=\"Communications Orales\">\n<h2>Communications Orales<\/h2>\n<p><strong>Journ\u00e9e Doctorale UHA<\/strong><\/p>\n<ul>\n<li>\u00ab\u00a0Maladies du bois de la vigne : \u00e9tude d\u2019effecteurs de Botryosphaeriaceae\u00a0\u00bb. <strong>Alexia GRAU<\/strong>, Mulhouse, 14 juin 2024.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>1\u00e8re Journ\u00e9e d\u2019\u00e9change entre les chercheurs et la profession viti-vinicole<\/strong><\/p>\n<ul>\n<li>\u00a0\u00bb Facteurs d\u2019agressivit\u00e9 de <em>Neofusicoccum parvum.\u00a0\u00bb <\/em><strong>Alexia GRAU, <\/strong>19 avril <strong>2024<\/strong> au LVBE, Colmar, France.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Docteur \u00e8s sciences au LVBE et attach\u00e9e temporaire d&rsquo;enseignement et de recherche (ATER)<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":2537,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3492","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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